用于治疗癌症的meleimide衍生物、药物组合物以及方法

MELEIMId derivative for treating cancer, compositions and methods

Abstract

本发明涉及吡咯并喹啉基-吡咯-2,5-二酮化合物以及吡咯并喹啉基-吡咯烷-2,5-二酮化合物,以及这些化合物的制备方法。本发明还涉及包含吡咯并喹啉基-吡咯-2,5-二酮化合物以及吡咯并喹啉基-吡咯烷-2,5-二酮化合物的药物组合物。本发明提供了通过对有此需要的对象给予治疗有效量的本发明的吡咯并喹啉基-吡咯-2,5-二酮化合物或吡咯并喹啉基-吡咯烷-2,5-二酮化合物治疗细胞增生性疾病,例如癌症的方法。
The present invention relates to pyrroloquinolinyl-pyrrole-2,5-dione compounds and pyrroloquinolinyl-pyrrolidine-2,5-dione compounds, and methods of preparation of these compounds. The present invention also relates to pharmaceutical compositions comprising pyrroloquinolinyl-pyrrole-2,5-dione compounds and pyrroloquinolinyl-pyrrolidine-2,5-dione compounds. The present invention provides methods of treating a cell proliferative disorder, such as a cancer, by administering to a subject in need thereof a therapeutically effective amount of a pyrroloquinolinyl-pyrrole-2,5-dione compound or pyrroloquinolinyl-pyrrolidine-2,5-dione compound of the present invention.

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